2009

26) Interpretable Features for the Activity Prediction of Short Antimicrobial Peptides Using Fuzzy Logic

Mikut R, Hilpert K.

Int J Pept Res Ther. In press.

 

25) Identification of Novel Antibacterial Peptides by Chemoinformatics and Machine Learning

Fjell CD, Jenssen H, Hilpert K; Cheung W, Panté N; Hancock REW; Cherkasov A.

J Med Chem. In press.

 

• 24) Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides

Ruden S, Hilpert K, Berditsch M, Wadhwani P, Ulrich AS.

Antimicrob Agents Chemother. In press.

 

• 23) Screening and characterization of surface-tethered cationic peptides for antimicrobial activity.

Hilpert K, Elliott M, Jenssen H, Kindrachuk J, Fjell CD, Körner J, Winkler DF, Weaver LL, Henklein P, Ulrich AS, Chiang SH, Farmer SW, Pante N, Volkmer R, Hancock REW.

Chem Biol. 2009;16(1):58-69.

 

• 22) Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs.

Hilpert K, Cherkasov A (both authors contributed equally, order changed), Jenssen H, Fjell CD, Waldbrook M, Mullaly SC, Volkmer R, Hancock REW.

ACS Chem Biol. 2009;4(1):65-74.

 

2008

• 21) Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genome.

Fjell CD, Jenssen H, Fries P, Aich P, Griebel P, Hilpert K, Hancock REW, Cherkasov A.

Proteins. 2008;73(2):420-30.

 

• 20) Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances.

Wiegand I, Hilpert K, Hancock REW.

Nat Protoc. 2008;3(2):163-75.

 

2007

• 19) Evaluating different descriptors for model design of antimicrobial peptides with enhanced activity toward P. aeruginosa.

Jenssen H, Lejon T, Hilpert K, Fjell CD, Cherkasov A, Hancock REW.

Chem Biol Drug Des. 2007;70(2):134-42.

 

• 18) Using intrinsic X-ray absorption spectral differences to identify and map peptides and proteins.

Stewart-Ornstein J, Hitchcock AP, Hernández Cruz D, Henklein P, Overhage J, Hilpert K, Hale JD, Hancock REW.

J Phys Chem B. 2007;111(26):7691-9.

 

• 17) Use of luminescent bacteria for rapid screening and characterization of short cationic antimicrobial peptides synthesized on cellulose using peptide array technology.

Hilpert K, Hancock REW.

Nat Protoc. 2007;2(7):1652-60.

 

• 16) Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion.

Hilpert K, Winkler DF, Hancock REW.

Nat Protoc. 2007;2(6):1333-49.

 

•15)  Antibacterial Host Defence Peptides of Bovine Origin

Jenssen H, Hilpert K, Hancock REW.

Journal Chimica Oggi/CHEMISTRY TODAY 2007;25(3):17-19.

 

• 14) Cellulose-bound peptide arrays: preparation and applications.

Hilpert K, Winkler DF, Hancock REW.

Biotechnol Genet Eng Rev. 2007;24:31-106.

 

2006

• 13) Sequence requirements and an optimization strategy for short antimicrobial peptides.

Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock REW.

Chem Biol. 2006;13(10):1101-7.

 

2005

• 12) Complete substitutional analysis of a sunflower trypsin inhibitor with different serine proteases.

Hilpert K, Hansen G, Wessner H, Volkmer-Engert R, Höhne W.

J Biochem. 2005;138(4):383-90.

 

• 11) High-throughput generation of small antibacterial peptides with improved activity.

Hilpert K, Volkmer-Engert R, Walter T, Hancock REW.

Nat Biotechnol. 2005;23(8):1008-12. (Covered in Nature Drug Discovery)

 

• 10) Unraveling sub-site specificities of peptidic serine protease inhibitors by substitutional and structural analysis.

Höhne W, Hilpert K.

Protein Pept Lett. 2005;12(5):449-56.

 

2004

• 9) Crystallization and preliminary x-ray analysis of complexes of porcine pancreatic elastase with two natural inhibitors.

Hilpert K, Wessner H, Scholz C, Scheerer P, Volkmer-Engert R, Krauss N.

Protein Pept Lett. 2004;11(4):393-9.

 

2003

• 8) Design and characterization of a hybrid miniprotein that specifically inhibits porcine pancreatic elastase.

Hilpert K, Wessner H, Schneider-Mergener J, Welfle K, Misselwitz R, Welfle H, Hocke AC, Hippenstiel S, Höhne W.

J Biol Chem. 2003;278(27):24986-93.

 

• 7) Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution.

Hilpert K, Aÿ J (both authors contributed equally, order changed), Krauss N, Schneider-Mergener J, Höhne W.

Acta Crystallogr D Biol Crystallogr. 2003;59(Pt 2):247-54.

 

2002

• 6) Crystallization and preliminary X-ray analysis of the complex of porcine pancreatic elastase and a hybrid squash inhibitor.

Hilpert K, Schneider-Mergener J, Aÿ J.

Acta Crystallogr D Biol Crystallogr. 2002;58(Pt 4):672-4.

 

2001

• 5) Anti-c-myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose.

Hilpert K, Hansen G, Wessner H, Küttner G, Welfle K, Seifert M, Höhne W.

Protein Eng. 2001;14(10):803-6.

 

2000

• 4) Characterizing and optimizing protease/peptide inhibitor interactions, a new application for spot synthesis.

Hilpert K, Hansen G, Wessner H, Schneider-Mergener J, Höhne W.

J Biochem. 2000;128(6):1051-7.

 

• 3) A novel method for characterizing protease/inhibitor interaction by using peptide
  synthesis on cellulose.

Hilpert K, Hansen G, Wessner H, Schneider-Mergener J, Höhne W.

Biotechnology 2000;2:73-75,

 

• 2) Atomic resolution structure of native porcine pancreatic elastase at 1.1 A.

Würtele M, Hahn M, Hilpert K, Höhne W.

Acta Crystallogr D Biol Crystallogr. 2000;56(Pt 4):520-3.

 

1999

• 1) Interaction of the capsid protein p24 (HIV-1) with sequence-derived peptides: influence on p24 dimerization.

Hilpert K, Behlke J, Scholz C, Misselwitz R, Schneider-Mergener J, Höhne W.

Virology. 1999;254(1):6-10.